An abnormal growth of tissue resulting from uncontrolled, progressive multiplication of cells and serving no physiological function.With increased knowledge of tumor cell biology, a new era of cancer therapeutics has evolved that are vastly different from conventional cytotoxic chemotherapy.This session elaborates on how greater understanding of mechanisms of cellular proliferation, oncogenic molecular mutations, importance of tumor bed vasculature, and the intricate balance between the immune system and tumor cells has allowed for tailored therapy guided by underlying pathology.