KEY NOTE

KEY NOTE

Abstract: Ovulation, which is induced by the ovulatory luteinizing hormone (LH) surge in vertebrates, is a dynamic process that results in a discharge of one or more fertilizable oocytes from the ovarian follicle into the ovarian cavity or into the abdominal cavity....
Accepted Poster

Accepted Poster

Abstract: DLK1 and DLK2 are transmembrane proteins known to be involved in the regulation of cell differentiation processes, such as adipogenesis, through the negative modulation of NOTCH signaling. Here, we examinate their possible roles in the osteogenic...
Accepted Poster

Accepted Poster

Abstract: The purpose of this work is to analyse the role of NOTCH receptors on the osteoblastic differentiation of mesenchymal C3H10T1/2 cells. To reach this objective cell populations stably overexpressing each of the four NOTCH receptors were generated by...
Accepted Poster

Accepted Poster

Abstract: NOTCH receptor signaling has been implicated in the development of triple-negative breast cancer tumors. DLK2 protein, a non-canonical NOTCH signaling inhibitor has previously been shown to be involved in skin cancer. In this work, we studied whether...
Accepted Poster

Accepted Poster

Abstract: We analyzed the role of DLK1 protein, an inhibitor of NOTCH receptors, in the osteogenic differentiation of MC3T3-E1 pre-osteoblastic cells, which lack endogenous Dlk1 expression. We have generated pools of cells stably overexpressing DLK1 protein by plasmid...
Accepted Lecture

Accepted Lecture

Abstract: Metastatic small cell lung cancer (SCLC) is not curable. While SCLC is initially sensitive to chemotherapy, remissions are short-lived. The relapse is induced by chemotherapy- selected tumor stem cells, which express the AC133 epitope of the CD133 stem cell...
Accepted Lecture

Accepted Lecture

Abstract: Injuries to the cell membrane of cancer cells, which are caused from invasive behavior, enhanced membrane dynamic and metabolic stress pose lethal threats to cancer cells. However, cancer cells cope by activating their plasma membrane repair system, which...
Accepted Lecture

Accepted Lecture

Abstract: In this study, we characterised and evaluated the anticancer activity of the antimicrobial peptides (AMP)s excreted by Anabas testudineus. To induce AMPs production, A. testudineus was exposed to heat de-activated Pseudomonas aeruginosa for 10 days. The...
Accepted Lecture

Accepted Lecture

Abstract: The identification of novel physiological regulators that stimulate energy expenditure through brown adipose tissue (BAT) activity in substrate catalysis is of utmost importance to understand and treat metabolic diseases. Myoglobin (MB), known to store or...
Accepted Lecture

Accepted Lecture

Abstract: MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using TargetScan and miRdB databases was performed to identify...
Accepted Lecture

Accepted Lecture

Abstract: Globally, efforts to advance malaria control and prevention have focused on two main areas of research: (1) Finding vaccine candidates to immunize populations and prevent posterior infections, (2) Finding novel and unknown molecules and fields where remain...
KEY NOTE

KEY NOTE

Abstract: Small cell lung cancer (SCLC) remains a major challenge in public health because of its frequency, its lethality, and the paucity of convenient models for exploring its pathogenesis and potential therapeutic vulnerabilities. Despite recent research advances,...
ACCEPTED LECTURE

ACCEPTED LECTURE

Abstract: Protein posttranslational modifications (PTMs) play essential roles in the regulation of almost all biological processes, ranging from DNA replication and gene expression to metabolism. The dysregulation of proteins PTMs often leads to human diseases such as...
ACCEPTED LECTURE

ACCEPTED LECTURE

Abstract: Hepatitis C virus infection is endemic in Egypt with the highest prevalence rate in the world. Without treatment, most acute infections lead to chronic, followed by cirrhosis and hepatocellular carcinoma. Sofosbuvir acts like a nucleos(t)ide analogue that...
ACCEPTED LECTURE

ACCEPTED LECTURE

Abstract: The COVID-19 disease has recently become one of the biggest challenges globally, and there is still no specific medication. Findings showed the immune system in severe COVID-19 patients loses regulatory control of pro-inflammatory cytokines, especially IL-6...
ACCEPTED LECTURE

ACCEPTED LECTURE

Abstract: The pandemic of SARS-CoV-2 stimulates efforts and approaches to understand its global spread. Although the recent introduction of the vaccine is a crucial prophylactic step, the effective treatment for SARS-CoV-2 is still undiscovered. A deep evaluation of...
ACCEPTED LECTURE

ACCEPTED LECTURE

Abstract: The virus that caused the COVID 19 pandemic spread globally with an increase in deadly infections in most countries, COVID-19 is caused by SARS-coronavirus-2 (SARS-CoV-2), which belongs to the coronavirus family and is related to Severe Acute Respiratory...
ACCEPTED LECTURE

ACCEPTED LECTURE

Abstract: Anoikis is a programmed cell death that occurs when cells lose their attachment to the extracellular matrix (ECM). Cell adhesion plays an important role in neoplastic transformation. Tumors produce several molecules that facilitate their proliferation,...
Accepted Lecture

Accepted Lecture

Abstract: This case report describes a fetus with compound heterozygosity for Hb G-Hsi-Tsou and beta thalassemia, diagnosed in a healthy pregnancy. To the best of our knowledge, this is the first documented case of compound heterozygosity and the woman is the second...
Accepted Lecture

Accepted Lecture

Abstract: The final manifestation of immune responses is a result of a complex interaction of phenotypically and functionally different cell populations. Mesenchymal stromal cell-like (MSCl) cells are considered to be an eligible cell line to model the...
Accepted Lecture

Accepted Lecture

Abstract: Smoking tobacco is the major hazard for lung cancer in Indian subcontinent especially men, compare to woman where, other important risk factors such as air pollutions are responsible. So, the aim of the study is to compare chronic smokers (CS) and...
Accepted Poster

Accepted Poster

Abstract: Indigofera cordifolia Heyne ex Roth. so far is reported only in the Arabian Peninsula from Oman. A recent field expedition in the Farasan Archipelago, Saudi Arabia, Red Sea, resulted in documentation of this species in Dumsuk Island. Morphological...
Accepted Lecture

Accepted Lecture

Abstract: Mimosa, one of the most species-rich genera in the Leguminosae, exhibits a high diversity of trichomes. These structures are considered crucial to the taxonomy of the genus and are commonly used to delimit infrageneric groups. The last taxonomic revision by...
Accepted Lecture

Accepted Lecture

Abstract: Direct visualization of the key features of coronavirus genomes and peptides can lead to a better understanding of this virus as well as to distinguish the mutant strains. The current study developed Java tools DNA nucleotide footprint plotter and peptide...
ACCEPTED LECTURE

ACCEPTED LECTURE

Abstract: Digital pathology is rapidly evolving, transforming qualitative paradigms to quantitative ones, increasing histological examination objectivity. With a compound annual growth rate of the market over 10%, scanning devices with a higher slide capacity, speed...
accepted poster

accepted poster

Abstract: Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. Studies focused on the reciprocal interactions of melanoma and immune cells demonstrated that microenvironment-derived tumour necrosis factor (TNF-α)...
accepted lecture

accepted lecture

Abstract: Histoplasmosis is a dangerous deep systemic mycosis that occurs in people even with preserved immune status, which can occur as respiratory distress syndrome, tuberculosis and other deseases. The importance of verification of diagnosis is associated with the...
accepted lecture

accepted lecture

Abstract: Induction of the Phase 2 enzymes is a major strategy in the chemoprotection against cancer. Inducers belong to nine different chemical classes. In this contribution we found that a measure of the tendency of thirty plant phenylpropenoids and synthetic...
accepted lecture

accepted lecture

Abstract: Background. Hand-assisted laparoscopic donor nephrectomy (HALDN) has rapidly become the best alternative to open nephrectomy for living kidney donation. As more centers continue to adopt the laparoscopic technique, the safety of the initial transplants must...
accepted lecture

accepted lecture

Abstract: Monoclonal antibodies (MAbs) are rapidly growing class of therapeutic molecules in biopharmaceuticals. More than 80 therapeutic antibodies have been approved by the FDA in the last 30 years for different indications ranging from oncology to autoimmune...
accepted lecture

accepted lecture

Abstract: Patients with myopia are at increased risk for the development of glaucoma. The inability to correct for axial length on spectral domain OCT (SD-OCT) imaging translates into a lower signal strength and scan reliability in patients with high myopia. We...
accepted lecture

accepted lecture

Abstract: Biological therapies such as immunotherapy and oncolytic virotherapy are physiological and well tolerated by cancer patients. The combination of cancer vaccines with oncolytic viruses is a powerful concept. Two types of autologous cancer vaccines will be...
accepted lecture

accepted lecture

Abstract: It has been noticed since ancient times that colds may cause all kinds of diseases. However, its underlying mechanism has not been fully elucidated so far. Located at the back of the nasal cavities, the epipharynx is a unique tissue that is vulnerable to the...
accepted lecture

accepted lecture

Abstract: Autophagy is a natural process which in physiological conditions is aimed at the elimination of destroyed or malfunctioning cell parts, organelles or molecules. Also, autophagy gets induced under stressing conditions in response to, for example, infection,...
accepted lecture

accepted lecture

Abstract: Human activity is a serious cause of huge changes in the environment and a constant reason for the emergence of new stress factors. Thus, to survive and reproduce, organisms must constantly implement a program of adaptation to continuously changing...
accepted lecture

accepted lecture

Abstract: Our group has been working on the implication of adherent-invasive Escherichia coli (AIEC) in the etiology of Crohn’s disease (CD). We have showed that AIEC abnormally colonize the intestinal mucosa of CD patients, adhere to and invade intestinal epithelial...
accepted lecture

accepted lecture

Abstract: Multiple sclerosis (MS) is a chronic disorder characterized by multifocal inflammatory infiltrates (T cells, B cells, macrophages) within the central nervous system (CNS) and concomitant degradation of myelin, oligodendrocytes and axons, along with reactive...
accepted lecture

accepted lecture

Abstract: mRNA decay is required for many biological events, and dysregulation of the mechanism leads to disorders, including cancer, neurodegenerative diseases and diabetes. A shortening of poly(A) tails (deadenylation) triggers mRNA degradation, that is mainly...
accepted lecture

accepted lecture

Abstract: SELEX technique is employed to select aptamers against wide range of targets. The in vitro method of aptamer selection using live cells as the target is referred as CELL-SELEX. The use of aptamers as therapeutic and diagnostic agents is rapidly evolving,...
accepted lecture

accepted lecture

Abstract: To characterize the pathobiology of solar lentigos (SLs), analyses by semiquantitative RT-PCR, Western blotting, and immunohistochemistry revealed the upregulated expression of endothelin (EDN)-1/endothelin B receptors (EDNBRs), stem cell factor (SCF)/c-KIT,...
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