by Cell Science & Molecular Biology | Aug 5, 2022
Abstract: Ovulation, which is induced by the ovulatory luteinizing hormone (LH) surge in vertebrates, is a dynamic process that results in a discharge of one or more fertilizable oocytes from the ovarian follicle into the ovarian cavity or into the abdominal cavity....
by Cell Science & Molecular Biology | Aug 5, 2022
Abstract: Background & Aims: Maternal liver exhibits robust adaptations to pregnancy to accommodate the metabolic needs of developing and growing placenta and fetus by largely unknown mechanisms. We found that achaete-scute homolog-like 1 (Ascl1), a gene encoding...
by Cell Science & Molecular Biology | Aug 5, 2022
Abstract: Background: With advent of Hyperthermic Intraperitoneal chemotherapy, the 5-yr survival improved significantly in advanced ovarian cancer. HIPEC might have role in ovarian tumor-microenvironment. Methodology: We included 30 patients with FIGO stage III to IV...
by Cell Science & Molecular Biology | Aug 5, 2022
Abstract: In eukaryotic cells, transcription and translation processes are physically separated by the nuclear envelope (NE). Newly transcribed mRNAs must be exported to the cytoplasm for protein synthesis, while some proteins require to be imported into the nucleus...
by Cell Science & Molecular Biology | Apr 27, 2022
Abstract: Natural products and their derivatives have long been recognized as a valuable source of therapeutic agents and they constitute a significant portion of currently approved drugs. Some of the challenges in the field of natural product research include early...
by Cell Science & Molecular Biology | Apr 27, 2022
Abstract: Background: Malaria is a major public health threat in tropical and subtropical countries. Rapid diagnostic in resource-limited settings remains a major obstacle to eliminate malaria, especially with the emergence of Plasmodium knowlesi. The present study...
by Cell Science & Molecular Biology | Apr 27, 2022
Abstract: About 7 % of men worldwide have problems to conceive, a situation that is related to 20-50 % cases of infertility. Besides, between 30-80 % of this affection has been related with oxidative stress, a factor that is also connected with genetic damage, such as...
by Cell Science & Molecular Biology | Apr 27, 2022
Abstract: Introduction: Ectodermal dysplasias (ED) are a group of approximately 200 clinical and congenital syndromes characterized by alterations in the development and homeostasis of two or more ectodermal structures. There is one case per one million people and one...
by Cell Science & Molecular Biology | Apr 27, 2022
Abstract: About 7 % of men worldwide have problems to conceive, a situation that is related to 20-50 % cases of infertility. Besides, between 30-80 % of this affection has been related with oxidative stress, a factor that is also connected with genetic damage, such as...
by Cell Science & Molecular Biology | Apr 27, 2022
Abstract: RNA binding proteins (RBPs) are highly abundant in eukaryotic cells and govern essential aspects of cellular function through interactions with their mRNA substrates and proteins. These ribonucleoprotein (RNP) complexes may further assemble into membraneless...
by Cell Science & Molecular Biology | Apr 27, 2022
Abstract: Graves’ disease is one of the most common autoimmune diseases affecting Indians, accounting for 50–80% of hyperthyroidism cases. The major morbidities associated with Graves’ disease are universally acknowledged. Thus, preventing metabolic syndrome could...
by Cell Science & Molecular Biology | Mar 24, 2022
Abstract: Small cell lung cancer (SCLC) remains a major challenge in public health because of its frequency, its lethality, and the paucity of convenient models for exploring its pathogenesis and potential therapeutic vulnerabilities. Despite recent research advances,...
by Cell Science & Molecular Biology | Mar 24, 2022
Abstract: Leucine-rich repeats (LRRs) occur in tandem and the repeat unit lengths (RULs) in general range from 20 to 29 residues. Seven LRR classes have been recognized. A comprehensive sequence analysis of viral LRRs has been done. Most proteins are from...
by Cell Science & Molecular Biology | Mar 24, 2022
Abstract: The most common symptoms of primary gastrointestinal (GI) lymphoma are non-specific, such as nausea, vomiting, diarrhea, weight loss, and abdominal pain. The rare acute symptoms include bowel obstruction, intussusception, and perforation. Primary small bowel...
by Cell Science & Molecular Biology | Mar 24, 2022
Abstract: Endometrial regeneration is a dynamic process that is not well understood. The destruction of the endometrium with the formation of intrauterine adhesions is known as Asherman’s syndrome. The lesions range from minor to severe adhesions and their impact on...
by Cell Science & Molecular Biology | Dec 14, 2021
Abstract: Iodothyronines are potent regulators of white adipose tissue functions and development. Endogenous 3,3’,5-triiodo-L-thyronine (T3) regulates lipolysis, lipogenesis, thermogenesis, and mitochondrial functions. However, excess of T3 induces heart rhythm...
by Cell Science & Molecular Biology | Dec 14, 2021
Abstract: Myopericarditis is a rare consequence of COVID-19 infection. Although extremely rare, COVID-19 can present without pulmonary involvement, and there have been reports of isolated cardiac involvement in one prior case We report a case of a young African...
by Cell Science & Molecular Biology | Dec 14, 2021
Abstract: Vision is essential for vertebrates including humans. Sustained vision is accomplished by the retinoid metabolism, ‘visual cycle’, where all-trans retinol (atROL) is released from photoreceptors upon light absorption and is incorporated into the adjacent...
by Cell Science & Molecular Biology | Dec 14, 2021
Abstract: Cadmium toxicity to animals depends on their tolerance mechanisms. The harmful action of this metal takes different forms, starting from blocking of intracellular signalling receptors, through induction of oxidative stress, to genotoxic effects. Cadmium...
by Cell Science & Molecular Biology | Sep 14, 2021
Abstract: Metastatic small cell lung cancer (SCLC) is not curable. While SCLC is initially sensitive to chemotherapy, remissions are short-lived. The relapse is induced by chemotherapy- selected tumor stem cells, which express the AC133 epitope of the CD133 stem cell...
by Cell Science & Molecular Biology | Sep 14, 2021
Abstract: Injuries to the cell membrane of cancer cells, which are caused from invasive behavior, enhanced membrane dynamic and metabolic stress pose lethal threats to cancer cells. However, cancer cells cope by activating their plasma membrane repair system, which...
by Cell Science & Molecular Biology | Sep 14, 2021
Abstract: The identification of novel physiological regulators that stimulate energy expenditure through brown adipose tissue (BAT) activity in substrate catalysis is of utmost importance to understand and treat metabolic diseases. Myoglobin (MB), known to store or...
by Cell Science & Molecular Biology | Sep 14, 2021
Abstract: Globally, efforts to advance malaria control and prevention have focused on two main areas of research: (1) Finding vaccine candidates to immunize populations and prevent posterior infections, (2) Finding novel and unknown molecules and fields where remain...
by Cell Science & Molecular Biology | Jul 6, 2021
Abstract: Hepatitis C virus infection is endemic in Egypt with the highest prevalence rate in the world. Without treatment, most acute infections lead to chronic, followed by cirrhosis and hepatocellular carcinoma. Sofosbuvir acts like a nucleos(t)ide analogue that...
by Cell Science & Molecular Biology | Apr 30, 2021
Abstract: This case report describes a fetus with compound heterozygosity for Hb G-Hsi-Tsou and beta thalassemia, diagnosed in a healthy pregnancy. To the best of our knowledge, this is the first documented case of compound heterozygosity and the woman is the second...
by Cell Science & Molecular Biology | Apr 30, 2021
Abstract: Indigofera cordifolia Heyne ex Roth. so far is reported only in the Arabian Peninsula from Oman. A recent field expedition in the Farasan Archipelago, Saudi Arabia, Red Sea, resulted in documentation of this species in Dumsuk Island. Morphological...
by Cell Science & Molecular Biology | Apr 30, 2021
Abstract: Mimosa, one of the most species-rich genera in the Leguminosae, exhibits a high diversity of trichomes. These structures are considered crucial to the taxonomy of the genus and are commonly used to delimit infrageneric groups. The last taxonomic revision by...
by Cell Science & Molecular Biology | Dec 14, 2020
Abstract: Digital pathology is rapidly evolving, transforming qualitative paradigms to quantitative ones, increasing histological examination objectivity. With a compound annual growth rate of the market over 10%, scanning devices with a higher slide capacity, speed...
by Cell Science & Molecular Biology | Mar 12, 2020
Abstract: Induction of the Phase 2 enzymes is a major strategy in the chemoprotection against cancer. Inducers belong to nine different chemical classes. In this contribution we found that a measure of the tendency of thirty plant phenylpropenoids and synthetic...
by Cell Science & Molecular Biology | Mar 3, 2020
Abstract: Monoclonal antibodies (MAbs) are rapidly growing class of therapeutic molecules in biopharmaceuticals. More than 80 therapeutic antibodies have been approved by the FDA in the last 30 years for different indications ranging from oncology to autoimmune...
by Cell Science & Molecular Biology | Feb 28, 2020
Abstract: Patients with myopia are at increased risk for the development of glaucoma. The inability to correct for axial length on spectral domain OCT (SD-OCT) imaging translates into a lower signal strength and scan reliability in patients with high myopia. We...
by Cell Science & Molecular Biology | Feb 28, 2020
Abstract: Biological therapies such as immunotherapy and oncolytic virotherapy are physiological and well tolerated by cancer patients. The combination of cancer vaccines with oncolytic viruses is a powerful concept. Two types of autologous cancer vaccines will be...
by Cell Science & Molecular Biology | Feb 17, 2020
Abstract: It has been noticed since ancient times that colds may cause all kinds of diseases. However, its underlying mechanism has not been fully elucidated so far. Located at the back of the nasal cavities, the epipharynx is a unique tissue that is vulnerable to the...
by Cell Science & Molecular Biology | Feb 17, 2020
Abstract: Autophagy is a natural process which in physiological conditions is aimed at the elimination of destroyed or malfunctioning cell parts, organelles or molecules. Also, autophagy gets induced under stressing conditions in response to, for example, infection,...
by Cell Science & Molecular Biology | Feb 17, 2020
Abstract: Human activity is a serious cause of huge changes in the environment and a constant reason for the emergence of new stress factors. Thus, to survive and reproduce, organisms must constantly implement a program of adaptation to continuously changing...
by Cell Science & Molecular Biology | Dec 31, 2019
Abstract: Wound healing consists of an organized cascade of biochemical and cellular events that involve tissue repairs and regeneration. Hibiscus sabdariffa (HS) content of polyphenols may participate by its antioxidant and anti-inflammatory properties necessary for...
by Cell Science & Molecular Biology | Dec 31, 2019
Abstract: Obtaining sufficient donor islet β-like cells is the key to islet transplantation for type 1 diabetes mellitus. Bone marrow mesenchymal stem cells (BMMSCs) are expected to be ideal sources to obtaining islet β-like cells, however the low differentiation rate...
by Cell Science & Molecular Biology | Dec 31, 2019
Abstract: The current study aims to analyze the length polymorphisms in sequence-tagged-site (STS) sY1291 of the Y chromosome in Vietnamese men of infertile couples. All 322 DNA samples were amplified with the sY1291 primer by the quantitative fluorescent polymerase...
by Cell Science & Molecular Biology | Nov 12, 2019
Abstract: Multiple sclerosis (MS) is a chronic disorder characterized by multifocal inflammatory infiltrates (T cells, B cells, macrophages) within the central nervous system (CNS) and concomitant degradation of myelin, oligodendrocytes and axons, along with reactive...
by Cell Science & Molecular Biology | Nov 12, 2019
Abstract: SELEX technique is employed to select aptamers against wide range of targets. The in vitro method of aptamer selection using live cells as the target is referred as CELL-SELEX. The use of aptamers as therapeutic and diagnostic agents is rapidly evolving,...
by Cell Science & Molecular Biology | Nov 12, 2019
Abstract: To characterize the pathobiology of solar lentigos (SLs), analyses by semiquantitative RT-PCR, Western blotting, and immunohistochemistry revealed the upregulated expression of endothelin (EDN)-1/endothelin B receptors (EDNBRs), stem cell factor (SCF)/c-KIT,...
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