Day2

  • Hokkaido University, Japan
  • Title:Prostaglandins in Teleost Ovulation: A Review of the Roles with a view to Comparison with Prostaglandins in Mammalian Ovulation.
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Abstract:
Ovulation, which is induced by the ovulatory luteinizing hormone (LH) surge in vertebrates, is a dynamic process that results in a discharge of one or more fertilizable oocytes from the ovarian follicle into the ovarian cavity or into the abdominal cavity. Follicle rupture is a core event of the ovulatory process and has been the subject of intensive investigation. Prostaglandins are well known to be central regulators of vertebrate ovulation. Studies addressing the role of prostaglandins in mammalian ovulation have established that they are involved in the processes of oocyte maturation and cumulus oocyte complex expansion. In contrast, despite the first indication of the role of prostaglandins in teleost ovulation appearing 40 years ago, the mechanistic background of their role has long been unknown. However, studies conducted on the teleost medaka over the past decade have provided valuable information. Emerging evidence indicates a critical role of prostaglandin E2 and its receptor subtype Ptger4b in the process of follicle rupture. In addition, our studies have revealed that activation of the melatonin/melatonin receptor system in the ovulating follicle is required for the prostaglandin E2-mediated follicle rupture process. In this talk, we summarize studies addressing the role of prostaglandins in teleost ovulation and describe recent advances. To help understand differences from and similarities to ovulation in mammalian species, the findings on the roles of prostaglandins in mammalian ovulation are discussed in parallel.
Biography:
Dr. Takayuki Takahashi, Ph.D., Emeritus Professor of Hokkaido University, Japan In 1979 Ph.D. in Zoology (Hokkaido University) from 1980-1986 Research Associate, Protein Studies Lab at Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA from 1987-1993 he is an Assistant Professor, Faculty of Science, University of Tokyo, Japan from 1993-2016 he is an Professor, Faculty of Science, Hokkaido University, Japan from 2016-2019 he is a
Research Professor, Hokkaido University, Japan.His research activities are in the field of reproductive biology of vertebrates including fish. In particular, his laboratory has been closely associated with ovulation studies using a teleost medaka by cellular and molecular biological approaches. His final goal is to get insights into the evolutional aspect of ovulation in the animal kingdom. Achievements: They were the first to report that, using the teleost medaka, (i) MMPs and plasminogen activator/plasmin are involved in follicle rupture during ovulation (PNAS, 2005; Biol. Reprod., 2012, 2015). In addition, they studies showed that (ii) many ovulation-related-genes are induced by the surge of LH at ovulation (PLoS ONE, 2013; Biol. Reprod., 2014; MCE, 2017), (iii) activation of
the prostaglandin E2 and the receptor system is required for follicle rupture (MCE, 2011, 2012, 2017; Biol. Reprod., 2016), and (iv) follicle rupture during ovulation is the process which proceeds under precise endocrine control (MCE, 2017; Reproduction, 2019; cells, 2019).
Award
In 2010, Prize from the Zoological Society of Japan
“Discovery of ovulatory proteases and elucidation of follicle rupture mechanism in teleost medaka”

  • University hospital of Freiburg, Germany
  • Title:Enhanced AC133-Specific CAR T Cell Therapy Induces Durable Remission in Mice with Metastatic Small Cell Lung Cancer.
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Abstract:
Metastatic small cell lung cancer (SCLC) is not curable. While SCLC is initially sensitive to chemotherapy, remissions are short-lived. The relapse is induced by chemotherapy- selected tumor stem cells, which express the AC133 epitope of the CD133 stem cell marker. We studied the effectiveness of AC133-specific CAR T cells post-chemotherapy using human primary SCLC and an orthotopic xenograft mouse model. AC133-specific CAR T cells migrated to SCLC tumor lesions, reduced the tumor burden, and prolonged survival in a humanized orthotopic SCLC model, but were not able to entirely eliminate tumors. We identified CD73 and PD-L1 as immune-escape mechanisms and combined PD-1-inhibition and CD73-inhibition with CAR T cell treatment. This triple-immunotherapy induced cures in 25% of the mice, without signs of graft-versus-host disease or bone marrow failure. AC133+ cancer stem cells and PD-L1+CD73+ myeloid cells were detectable in primary human SCLC tissues, suggesting that patients may benefit from the triple-immunotherapy. We conclude that the combination of AC133-specific CAR T cells, anti-PD-1-antibody and CD73-inhibitor specifically eliminates chemoresistant tumor stem cells, overcomes SCLC-mediated T cell inhibition, and might induce long-term complete remission in an otherwise incurable disease.
Biography:
Dr. Sanaz Taromi current Position: Professor in Faculty Medical and Life Sciences University Furtwangen. Group Leader in Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center – University of Freiburg, Germany. Research: She is molecular biologist; her research is concentrated on the development of novel CAR T cell-based approaches against SCLC. She is conducting preclinical studies on the mechanisms of SCLC metastasis formation, inhibitory tumor microenvironment, and stem cell-based resistance and T cell infiltration of solid tumors.

  • Danish Cancer Society Research Center, Denmark
  • Title:Compromising Plasma Membrane Repair in Cancer Cells.
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Abstract:
Injuries to the cell membrane of cancer cells, which are caused from invasive behavior, enhanced membrane dynamic and metabolic stress pose lethal threats to cancer cells. However, cancer cells cope by activating their plasma membrane repair system, which depends on mechanisms to remove damaged membrane by excision, internalization by endocytosis or reorganization of actin around the hole to reseal the wound. Proteins belonging to the annexin family are often found highly expressed in various cancer types and are characterized by their Ca2+-dependent binding to anionic phospholipids in the plasma membrane. Annexin family members share the ability to glue adjacent membranes together during wound healing but our recent results show that they play roles that are more specific in membrane repair by regulation of membrane excision, shedding, and induction of membrane curvature in cancer cells. Our findings open a novel avenue to target cancer cells by compromising annexin mediated plasma membrane repair. Here, novel molecular aspects of targeting the membrane repair system in cancer cells by phenothiazines, which alter plasma membrane properties and sensitize to membrane injury by inhibiting annexin-mediated repair will be presented.
Biography:
Dr. Jesper Nylandsted is Group Leader at the Danish Cancer Society Research Center in Copenhagen. His work focuses on alternative death pathways and repair mechanisms in cancer cells and novel approaches to target these processes. Using biophysical methods and live cell imaging, his group has revealed fundamental processes in cell death signalling and plasma membrane repair mechanisms of cancer cells.

  • University of Zurich, Switzerland
  • Title:Myoglobin, Expressed in Brown Adipose Tissue of Mice, Regulates the Content and Activity of Mitochondria and Lipid Droplets.
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Abstract:
The identification of novel physiological regulators that stimulate energy expenditure through brown adipose tissue (BAT) activity in substrate catalysis is of utmost importance to understand and treat metabolic diseases. Myoglobin (MB), known to store or transport oxygen in heart and skeletal muscles, has recently been found to bind fatty acids with physiological constants in its oxygenated form (i.e., MBO2). Here, we investigated the in vivo effect of MB expression on BAT activity. In particular, we studied mitochondrial function and lipid metabolism as essential determinants of energy expenditure in this tissue. We show in a MB-null (MBko) mouse model that MB expression in BAT impacts on the activity of brown adipocytes in a twofold manner: i) by elevating mitochondrial density plus maximal respiration capacity, and through that, by stimulating BAT oxidative metabolism along with the organelles` uncoupled respiration; and ii) by influencing the free fatty acids pool towards a palmitate-enriched composition and shifting the lipid droplet (LD) equilibrium towards higher counts of smaller droplets. These metabolic changes were accompanied by the up-regulated expression of thermogenesis markers UCP1, CIDEA, CIDEC, PGC1-α and PPAR-α in the BAT of MB wildtype (MBwt) mice. Along with the emergence of the “browning” BAT morphology, MBwt mice exhibited a leaner phenotype when compared to MBko littermates at 20 weeks of age. Our data shed novel insights into MB’s role in linking oxygen and lipid-based thermogenic metabolism. The findings suggest potential new strategies of targeting the MB pathway to treat metabolic disorders related to diminishing energy expenditure.
Biography:
Dr. Thomas A. Gorr: from 1982-1988:Study of Biology, in Philipps-University Marburg, Marburg, Germany; from 1989-1993:PhD thesis in Protein Chemistry at the Max-Planck-Institute for Biochemistry, Martinsried, Germany; in 1994:Dr. rer. nat. (PhD), Ludwig-Maximilians-University, Munich, Germany; from 1994-2004:postdoctoral stay in USA: a) UT Austin TX; b) Harvard Medical School; in 2005-today:Leader of independent hypoxia/metabolism research group; Univ. Zurich; 2014:Habilitation (PD) in Comparative Physiology, Vetsuisse Faculty, University Zurich.

  • National University of Colombia, Colombia
  • Title:Characteristics of PlasWD-40-1 and the HSP70-2/BiP/GRP78 Homolog PfHSP70-2 Proteins, their Possible Correlation, Role in Exporting Proteins Beyond its Shore
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Abstract:
Globally, efforts to advance malaria control and prevention have focused on two main areas of research: (1) Finding vaccine candidates to immunize populations and prevent posterior infections, (2) Finding novel and unknown molecules and fields where remain interesting questions unsolved. The intracellular malaria parasite Plasmodium falciparum organization, particular organelles as endoplasmic reticulum and domains of the infected erythrocytes affected by changes and modifications to evading the immune response, are important basic studies. P. falciparum export virulent proteins and built a complex cell modified to transport proteins traversing three concentric membranes or cellular compartments as; plasmatic membrane of the parasite, parasitophorous vacuolar membrane, and plasmatic membrane of infected erythrocyte getting alterations for own benefit and survive. Released merozoites ending the intraerythrocytic cycle after 48 hours of the invaded cell cause symptoms of disease, physiopathology and are highly immunogenic. Our group prepared monoclonal antibodies to study the event that occurs when merozoites egress from their host, this immunogen inoculated to generate the antibodies recognizing proteins localized in the Protein export compartment (PEC). PEC is a domain of the endoplasmic reticulum that could be associated with egress merozoites. However, before studying this event, it is necessary to know the identity of proteins localized in PEC. One of the proteins localized is named Pf68kDa, which is the first resident protein of PEC, identified and is recognized by a monoclonal antibody, mAb7.
We show identification of the 68 kDa antigen of P. falciparum. Recently works identified Pf68 kDa as two proteins by different methodological strategies, and the same mAb7: the first protein identified as a homolog of HSP70/BiP/GRP78, named PfHSP70-2 by affinity chromatography and mass spectrometry, and the second protein identified, Plasmodium WD40 repeat-containing protein-1 (PlasWD40-1) identified from a cDNA expression library screened with Mab7. From the plaques analyzed, two positive clones ultimately were identified. Thus, Mab7 not only recognizes PfHSP70-2 but also recognizes a protein expressed by the cloned DNA fragment (MK618679). Now, We know more about the nature of PEC, and not much about PlasWD40 and Pf68kDa is not precisely known. It is unknown if a common epitope between PfHSP70-2 and PlasWD40-1 is a coincidence or both proteins are interacting or regulating functions to directing activities in the endoplasmic reticulum to exporting proteins to the plasmatic membrane of P. falciparum-infected erythrocytes. The target from these two proteins and common epitope or each one separately, could to proposing new possible therapeutic strategies against malaria.
Biography:
Dr. Gladys Thalia Cortes obtained her Ph.D. in Biotechnology from Science Faculty at Universidad Nacional de Colombia (2020), Master Science degree at Universidad Javeriana (1995), and specialization training in immunochemistry and cellular immunology at National Institute of Health from Tokyo (Japan, 1986). Her primary field is Bacteriologist. Her studies in cell Biology of Plasmodium began with profesor Winograd E. at the Instituto Nacional de Salud (Bogotá), Wiser M., as consultor and co-investigator from Tulane University. She continued searching the cell Biology of Plasmodium at National University of Colombia (2005- ) in collaboration with Biofísica y Biología de membranas, Dr. Camacho M. at Centro Internacional de Física, Public Health Department
at Faculty of Medicine. Her group published recently aspects related to, identification of antigen named Pf68 kDaPlasmodium falciparum resident protein of and specialized domain of the endoplasmic reticulum, or Plasmodium export compartment (PEC), PfHSP70-2 and (2020) and Plasmodium WD40 repeat-containing protein-1 (PlasWD40-1) identified from a cDNA expression library screened with Mab7 (2021), both proteins hypothesized as share a common epitope recognized by a same monoclonal antibody, mAb7 (doctoral thesis, 2019); besides, a study of release merozoites process from its host by photoconversion fluorescent compound to electron microscopy (2011), and characterization of proteins localized to a subcellular compartment associated with an alternate secretory pathway of the malaria parasite (2003). Currently, she is a Ph.D. researcher and professor of the Department of public health Faculty of Medicine at Universidad Nacional de Colombia.

  • University of Tartu, Estonia
  • Title:open-source solutions for whole slide imaging: an overview and possible application.
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Abstract:
Digital pathology is rapidly evolving, transforming qualitative paradigms to quantitative ones, increasing histological examination objectivity. With a compound annual growth rate of the market over 10%, scanning devices with a higher slide capacity, speed and resolution become available. Not of less importance is software, varying from free basic viewers ending with advanced machine learning algorithms promising (semi) automatic diagnosis. To a significant extent, the advantages of computer-assisted image analysis may first be experienced via open-source solutions. The session provides an overview of existing free WSI-oriented solutions and examples of possible applications in teaching, scientific research, and pathologists’ daily practice.
Biography:
Dr. Georgi Dzaparidze, the founder of Estonian Digital Pathology Association. Co-developer of the first digital-pathology department in Estonia. Co-author of digital pathology solutions for medical and medical technician students in Estonia.

  • Instituto de Cardiologa Calle, Colombia
  • Title:Type 2 Myocardial Infarction in a Patient with Acute Abdomen Due to an Incarcerated Amyand’s Hernia
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Abstract
Background: Type 2 myocardial infarction (MIT2) is characterized by higher mortality rates compared to conventional type 1 infarction according to the European Society of Cardiology (ESC) in 2018. The purpose of this case is to identify appropriate therapeutic measures. A case of an Amyand’s Hernia that produced an MIT2 is described in this work.
Case Report: A 77-year-old male was admitted to our emergency department for acute abdominal pain in the right lower quadrant associated with the presence of an ipsilateral inguinal hernia with signs of peritoneal irritation, while complaining of chest pain. A positive troponin indicated the presence of myocardial infarction. A laparotomy was performed with the finding of an incarcerated right inguinoscrotal hernia that contained the gangrenous and perforated cecal appendix (Amyand hernia type 3). The treatment consisted of surgical correction of the hernia, an appendectomy, antibiotics and support in the intensive care unit with a positive outcome. The diagnosis of Amyand hernia type 3 was established intraoperatively, and by imaging, confirming the presence of an MIT2 according to the criteria of the fourth definition of ECS infarction.
Conclusion: In the surgical environment it is strange to find patients who present with acute abdominal pain and a myocardial infarction at the same time. It is necessary for the consultant to recognize these two entities to make a correct diagnosis and provide timely treatment to reduce any possibility of patient mortality
Biography:
Dr. Silvia Barbosa is a physician at the Fundacion Cardioinfaltil in Bogota Colombia, She is a part of the research group of general surgery and emergency with the aim of improving and promoting the scientific development of her country and society. They are a leading hospital in Latin America and it is through science that they can get more answers every day by sharing knowledge.Her interest is to share the complexity of the human being, how two or more entities can appear in a single patient at the same time that they are different from each other but they are interconnected and our challenge is to define how to solve them all.

  • Lomonosov Moscow State University , Russia
  • Title:Antipodal Cells of the Embryo Sac of Wheat as a Unique Object to Study Plant Polytene Chromosomes
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Abstract:
Polytene chromosomes are interphase chromosomes consist of homologous chromatids, which are amplified through consecutive cycles of endoreduplication and conjugate together. Polytene chromosomes are formed in the nuclei of cells that require intense synthesis of substances in highly specialized tissues.
Antipodal cells of embryo sac of wheat is an example of plant cells with polytene chromosomes. Antipodal complex is located in the ovule between the nucellus and endosperm. Antipodal cells form a complex consisting of three cell layers – basal, which contacts with the conductive tissues, middle and apical, which contacts with the endosperm. After double fertilization antipodal cells produce substances necessary for the emerging endosperm coenocyte. Antipodal cells belong to the tissues that perform trophic and barrier functions between the maternal organism and the tissues formed after fertilization. So they play key role in development of endosperm and moreover are crucial for formation of endosperm in cultivated cereals, which are food for all the humanity.
The aim of our work was to study the morphology of the nuclei and giant polytene chromosomes of antipodal cells. The work was performed on total specimens of embryo sacs isolated from fixed wheat ovules. We used methods of light microscopy and transmission electron microscopy.
We measured DNA content in the nuclei of the antipodal cells and found that nuclear DNA content varies in the cells of the complex. The basal layer cells contain less DNA than apical layer cells. During the differentiation DNA content of nuclei increases.
Structure of antipodal polytene chromosome differ from structure of animal polytene chromosomes. Animal polytene chromosomes have disks and interdisks as a result of conjugation of chromatids along the entire length of the polytene chromosome. In regions of polytene chromosomes with the intensive synthesis of RNA, decondensation of chromatin occurs and puffs are formed. On the contrary antipodal cells are characterized by giant chromosomes in the form of bundles of threads and conjugation is found only in centromere regions. At the initial stages of the differentiation nuclei of antipodals have approximately the same size and nonsegregated polytene chromosomes. Then the nuclei of middle and apical layer cells increase in size, they have isolated individual chromosomes.
To conclude, the antipodal cells of the embryo sac in cereals are a unique object for solving the fundamental problems of cell biology and a convenient model for studying the structure of the nuclei and the stages of reforming polytene chromosomes during ontogenesis.

Biography:
Tatiana Doronina is a 2nd year PhD student in Lomonosov Moscow State University, Biology Faculty in Russia at the Department of Cell Biology and Histology. The field of interest is plant cell biology, polytene chromosomes and programmed cell death.
Publications:
•Doronina, T. V., Chaban, I. A., & Lazareva, E. M. 2019) Structural and Functional Features of the Wheat Embryo Sac’s Antipodal Cells during Differentiation. Russian Journal of Developmental Biology, 50(4), 194-208.
•Doronina, T. V., Chaban, I. A., & Lazareva, E. M. 2019. Structural reorganization of nuclei of wheat antipodal cells during programmed cell death. Biopolymers & Cell, 35(3), 206.

  • Dept RDDM , France
  • Title:Redox Properties of Mono- and Tri-Cyclic Cyanoenones Correlated with their Efficacy as Inducers of a Cytoprotective Phase 2 Enzyme and as Protectors against Inflammation: Potency Ranking
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Abstract:
Induction of the Phase 2 enzymes is a major strategy in the chemoprotection against cancer. Inducers belong to nine different chemical classes. In this contribution we found that a measure of the tendency of thirty plant phenylpropenoids and synthetic analogues to release electrons correlates linearly with their potency in inducing the activity of NAD(P)H:quinone reductase (NQO1), a prototypic Phase 2 cancer protective enzyme.  The tendency to release electrons was determined by the energy of the highest occupied molecular orbital (EHOMO), calculated by simple quantum mechanical methods. The correlations observed establish a clear conclusion: the smaller the absolute Energy of the Highest Occupied Molecular Orbital (EHOMO) of an agent, the greater its inducer potency, (i.e., the lower its oxidation potential, the stronger its electron donor property and the greater its inducer potency). The finding of this redox ranking of the inducers demonstrates that it is possible to predictively control the genetic expression of an enzymatic defense against cancer by xenobiotics via one physical parameter, their EHOMO.

  • USA
  • Title:Analysis of Glycosylation in Monoclonal Antibodies
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Abstract:
Monoclonal antibodies (MAbs) are rapidly growing class of therapeutic molecules in biopharmaceuticals. More than 80 therapeutic antibodies have been approved by the FDA in the last 30 years for different indications ranging from oncology to autoimmune diseases to respiratory diseases and the number is increasing year by year. Most of the current therapeutic antibodies are immunoglobulin G (IgG) with glycosylation constituting around 3% of the total mass of the molecule. Understanding the impact of glycosylation and close monitoring is critical for monoclonal antibodies and fusion proteins development as therapeutic molecule. Different forms of glycan including sialic acid (NANA/NGNA), galactose, mannose and fucose influence safety, efficacy and pharmacodynamics/pharmacokinetic property (PD/PK) of the therapeutic monoclonal antibodies and fusion proteins. This presentation will highlight the influence of different glycan variants on the drug’s behaviour in the body and draw attention to commonly employed analytical techniques to analyse therapeutic molecules and determine and quantify glycan composition, structure and glycosylation site in them.

Biography:
Dr Harleen Kaur has been in the pharmaceutical industry for almost 8 years and most recently led the analytics and drug product tech transfer projects for two biologics products while working at AstraZeneca, USA. Prior to this, she worked in R&D division of Fujitsu Asia Pte Ltd in Singapore where she worked on aptamer development and played an integral role in identifying and purifying aptamers against different protein targets in collaboration with National University of Singapore, Agency of Science Technology and Research Singapore, and Japanese diagnostic enterprise Sysmex. In her current role, she is leading a team of analytical scientists at Aurobindo Biologics and her responsibilities include the method development, method qualification and method transfer for different biosimilar products. she completed her PhD in chemical and biomolecular engineering department at National University of Singapore.

  • Johns Hopkins University School of Medicine,USA
  • Title:Use of Contact Lenses to Optimize Optical Coherence Tomography Scans of the Optic Nerve in Open Angle Glaucoma Suspects or Patients with Open Angle Glaucoma with High Myopia
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Abstract:
Patients with myopia are at increased risk for the development of glaucoma. The inability to correct for axial length on spectral domain OCT (SD-OCT) imaging translates into a lower signal strength and scan reliability in patients with high myopia. We evaluated the effectiveness of a contact lens to increase the signal strength, assess optic nerve dimensions and nerve fiber layer thickness using SD-OCT in patients with glaucoma or who are glaucoma suspects with high axial myopia.
Methods- A single-center, prospective, interventional study of patients with axial lengths over 25.5 mm with a diagnosis of glaucoma or glaucoma suspect. The optic nerve cube 200 x 200 scan using the Cirrus SD-OCT 400 was taken first without and then repeated after the placement of the contact lens. The primary outcome measure was the change in the average nerve fiber layer thickness before and after use of the contact lens. Secondary outcome measures included the change in cup volume, disc area, and rim area.
Results- Twelve patients were recruited (20 eyes) and the average axial length was 27.06 mm and the average signal strength interval increased by 1.73 (p= 0.001). With the use of a contact lens, the average nerve fiber layer thickness was significantly thicker. None of the changes in the secondary outcome measures were significant: rim area, cup volume, or disc area. Conclusions- Based on our data, the use of a contact lens statistically improved the signal strength and average nerve fiber layer thickness of the SD-OCT scan. The ability to accurately capture the perimeter of the optic disc can be limited in the setting of peripapillary atrophy, which was present in all but two subjects. Future studies with a larger number of subjects and a wider range of axial myopia to discern if contact lens correction has a greater effect on the highest axial lengths are needed.
Biography:
Dr. Meghan K. Berkenstock has become an emerging leader in the field of ocular immunology. She is an Assistant Professor of Ophthalmology at the Wilmer Eye Institute of the Johns Hopkins School of Medicine, her research focuses on quality improvement and identifying and treating ocular side effects of oncologic immunotherapy medications.

  • Immune-Oncological Center Cologne,Germany
  • Title:Cancer Vaccines Modified by Virus Infection: Concept, Mechanism of Function and Clinical Results
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Abstract:
Biological therapies such as immunotherapy and oncolytic virotherapy are physiological and well tolerated by cancer patients. The combination of cancer vaccines with oncolytic viruses is a powerful concept. Two types of autologous cancer vaccines will be described which are modified by infection with the avian Newcastle disease virus. They instruct the immune system about relevant cancer targets (tumor antigens, TAs) and contain signals for innate immunity activation. Viral molecular patterns such as S’-PPP RNA and hemagglutininneuraminidase (HN) protein initiate early inflammatory defense reactions which contribute to activation of antigen-presenting cells (APCs) and to costimulation of T cells. The concommitant stimulation of TA-specific CD4+ and CD8+ T cells occurs in T-APC clusters. These generate cancer-reactive cytotoxic T lymphocytes (CTLs) and T cell mediated long-term immunological memory. Results from pre-clinical and clinical studies will be presented.
Biography:
Dr. Volker Schirrmacher is a Scientific Director of Tumorimmunology at IOZK, Cologne, Germany. He finished his studies of biochemistry with a PhD in immunology. After 5 years post-doc time in Stockholm, Sweden and London, UK, he became Full Professor and Head of Division of Cellular Immunology at the German Cancer Research Center, Heidelberg, Germany. This position was hold for 32 years until official retirement in 2008. His scientific oevre covers more than 400 peer-reviewed publications and several books. He was awarded the Aronson Price, the Meyenburg Price and the German Cancer Award.

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