Background: With advent of Hyperthermic Intraperitoneal chemotherapy, the 5-yr survival improved significantly in advanced ovarian cancer. HIPEC might have role in ovarian tumor-microenvironment. Methodology: We included 30 patients with FIGO stage III to IV A advanced Epithelial ovarian cancer. We have seen the expression of FOXp3, RORɣ, Interleukin-10 and IL-17 in tumor and PBMC before and after HIPEC in and compared the changes of expression through FCM and RT-PCR.
Results: There was highest expression of FOXp3 mRNA in recurrent group followed by upfront and interval. There was statistically significant decrease in FOXp3 at four weeks in three subgroups. There was an increase in ROR-ɣ in 4 weeks in upfront and interval groups. Conclusions: HIPEC might have some role on ovarian tumor microenvironment, as we found in the expression of FOXp3 and Th17, thereby increasing the survival.
Dr M D Ray, MS, FRCS, FACS, PhD, an eminent onco-surgeon in premier institute, AIIMS, Delhi, India. He is a teacher, guide of MCh, Surgical Oncology superspeciality and PhD in clinico Molecular Oncology. He is an eminent Indian author in his profession as well as in literature. He published more than 110 papers ,11 Medical books and 21 books in literature. He believes ‘Humanity is the best religion.