Protein posttranslational modifications (PTMs) play essential roles in the regulation of almost all biological processes, ranging from DNA replication and gene expression to metabolism. The dysregulation of proteins PTMs often leads to human diseases such as cancer and neurodegenerative diseases. Therefore, it is of great importance to reveal the biological significance of protein PTMs and their regulatory mechanisms. Benefiting from the rapid development of mass spectrometry technology, the number of known PTMs has increased rapidly. However, only a handful of protein PTMs have been extensively studied, while the cellular mechanisms and functions of many other PTMs, particularly those newly identified ones, remains poorly understood. In this talk, I will present the new strategies and discoveries on the biological significance and regulation mechanism of several novel protein PTMs.
Dr. Bao received her bachelor’s degree in Biological Science from Nankai University and then completed her PhD in the field of Chemical Biology in Hong Kong University. Her dissertation has been selected for a Springer Thesis Award and published by Springer. Dr. Bao is now a Postdoctoral Fellow in Prof. Xiang David Li’s laboratory at Hong Kong University. Her research focuses on development of chemical biological strategies to decipher the biological functions of protein post-translational modifications (PTMs) and their regulatory mechanisms.