Abstract:
Iodothyronines are potent regulators of white adipose tissue functions and development. Endogenous 3,3’,5-triiodo-L-thyronine (T3) regulates lipolysis, lipogenesis, thermogenesis, and mitochondrial functions. However, excess of T3 induces heart rhythm abnormalities, muscle wasting, and reduced bone density, so that applying this hormone as a pharmacological compound has been discouraged in obesity and related diseases. 3,5-diiodo-L-thyronine (3,5-T2) seems to act through nuclear thyroid hormone receptors-independent pathways, with mitochondria as a likely cellular target. Specifically, 3,5-T2, when administered to rats receiving a high-fat diet (HFD), increases energy expenditure and prevents HFD-induced adiposity, without inducing alterations of the hypothalamus-pituitary-thyroid axis, and of skeletal muscle and heart mass. In HFD rats, by a combined approach, including large-scale expression profile and functional analyses, we demonstrated that 3,5-T2 has an anti adipogenic/lipogenic potential, in vivo modulating adipose tissue proteome, affecting proteins involved in lipid storage, oxidative stress, and lipogenesis-associated mitochondrial function. All this, combined with the previously described increased oxidative capacity of liver, expands on the notion of the prevention of fat mass-gain by 3,5-T2 and contributes to further explaining the action of this intriguing naturally occurring thyroid hormone metabolite.
Biography:
Dr.Elena Silvestri Born in Benevento, Italy. Associate professor of Physiology, University of Sannio, Benevento, Italy. Research themes: a) peripheral mediators of thyroid hormone action: diiodothyronines; b) mitochondria and cellular thermogenesis; c) thyroid hormones and uncoupling proteins; d) proteomics of metabolically active animal tissues under physio–pathological conditions (thyroid states, obesity, ageing, AD). Editorial activity Reviewer for several international journals. Co-Guest Editor for special issues of Nutrients and Frontiers in Endocrinology. Fellows – Since 2006 she is member of the Italian Physiology Society and since 2013 member of the European Thyroid Association (ETA). Awards – September 2021 – The ETA Max Pierre König Poster Award, in recognition of the best poster in basic thyroidology: Differential deranged liver pathways in genetically determined thyroid dysfunctions: intra- and extrahepatic factors, at the 43rd Annual Meeting of the Association 4th – 7th September 2021 -September 2008 – National Award for young researchers in Physiology (Società Italiana di Fisiologia) -July 2006 – The Italian Proteomic Association, Pisa, Italy. Beckam Coulter Aword in Proteomics (BeCap Beckman) 3,5,3′-Triiodo-L- Thyronine And Rat Liver Mitochondria Phenotype: A Proteomic Approach.

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