Iodothyronines are potent regulators of white adipose tissue functions and development. Endogenous 3,3’,5-triiodo-L-thyronine (T3) regulates lipolysis, lipogenesis, thermogenesis, and mitochondrial functions. However, excess of T3 induces heart rhythm abnormalities, muscle wasting, and reduced bone density, so that applying this hormone as a pharmacological compound has been discouraged in obesity and related diseases. 3,5-diiodo-L-thyronine (3,5-T2) seems to act through nuclear thyroid hormone receptors-independent pathways, with mitochondria as a likely cellular target. Specifically, 3,5-T2, when administered to rats receiving a high-fat diet (HFD), increases energy expenditure and prevents HFD-induced adiposity, without inducing alterations of the hypothalamus-pituitary-thyroid axis, and of skeletal muscle and heart mass. In HFD rats, by a combined approach, including large-scale expression profile and functional analyses, we demonstrated that 3,5-T2 has an anti adipogenic/lipogenic potential, in vivo modulating adipose tissue proteome, affecting proteins involved in lipid storage, oxidative stress, and lipogenesis-associated mitochondrial function. All this, combined with the previously described increased oxidative capacity of liver, expands on the notion of the prevention of fat mass-gain by 3,5-T2 and contributes to further explaining the action of this intriguing naturally occurring thyroid hormone metabolite.
Dr.Elena Silvestri Born in Benevento, Italy. Associate professor of Physiology, University of Sannio, Benevento, Italy. Research themes: a) peripheral mediators of thyroid hormone action: diiodothyronines; b) mitochondria and cellular thermogenesis; c) thyroid hormones and uncoupling proteins; d) proteomics of metabolically active animal tissues under physio–pathological conditions (thyroid states, obesity, ageing, AD). Editorial activity Reviewer for several international journals. Co-Guest Editor for special issues of Nutrients and Frontiers in Endocrinology. Fellows – Since 2006 she is member of the Italian Physiology Society and since 2013 member of the European Thyroid Association (ETA). Awards – September 2021 – The ETA Max Pierre König Poster Award, in recognition of the best poster in basic thyroidology: Differential deranged liver pathways in genetically determined thyroid dysfunctions: intra- and extrahepatic factors, at the 43rd Annual Meeting of the Association 4th – 7th September 2021 -September 2008 – National Award for young researchers in Physiology (Società Italiana di Fisiologia) -July 2006 – The Italian Proteomic Association, Pisa, Italy. Beckam Coulter Aword in Proteomics (BeCap Beckman) 3,5,3′-Triiodo-L- Thyronine And Rat Liver Mitochondria Phenotype: A Proteomic Approach.