It has been noticed since ancient times that colds may cause all kinds of diseases. However, its underlying mechanism has not been fully elucidated so far. Located at the back of the nasal cavities, the epipharynx is a unique tissue that is vulnerable to the effects of upper respiratory tract infections and air pollution. The epipharynx is an immunologically activated site even under normal conditions, and enhanced activation of innate immunity is likely to occur in response to airborne infection. In addition, the epipharynx has abundant distribution of vagal nerve fibers. Chronic epipharyngitis is not a widely understood condition. However, because of its close link with the nervous system and immune systems, it may play an important role as a trigger for the development of autoimmune diseases and neuroendocrine disorders, including chronic fatigue syndrome and other somatic symptoms. Thus, the epipharynx-brain interaction and epipharyngitis related immunity are worth consideration in managing patients with autonomic nervous disorder and patients with autoimmune disease. Given that chronic epipharyngitis and its brain interactions are not fully understood, it is important to focus future research on this condition.
Osamu Hotta, Medical Doctor (Ph.D.-medicine), now is a Director of Hotta Osamu Clinic, Clinical professor of Tohoku Medical and Pharmaceutical University, Councilor of Japanese Society of Nephrology, and Chairman for Japanese Focal Inflammation related Disease Research Group (JFIR). Osamu Hotta is a nephrologist, got Medical Doctor’s degree (Ph.D) at Tohoku University in 1993.